antipsyotic drug

TRADITIONAL/ TYPICAL

ATYPICAL

LOW POTENCY: · chlorpromazine (thorazine) · thioridazine (mellaril) HIGH POTENCY: · Haloperidol (haldol) · Fluphenazine (prolixin) · Trifluoperazine (stelazine) · Perphenazine (trilafon) · Pimozide (orap) DESCRIPTIONS · Lower affinity for dopamine receptors.high dose needed.not level of efficacy.it have increased incidence of anticholinergic & antihistaminic s/e. · High incidence of EPSEs and NEUROLEPTIC MALIGNANT SYNDROME. TREAT POSITIVE PSYCHOTIC SYMPTOMS SIDE EFFECTS: · Antidopaminergics effects: EPSE: - DYSTONIA of face, neck, tongue (few days) - AKATHISIA (restlessness) (after weeks) - PARKINSONISM (resting tremor, rigidity, bradykinesia- few months) - TARDIVE DYSKINESIA (high potency- after years) · Anti- HAM effects: - Sedation - Dry mouth - Cardiac, sexual prob · Weight gain · Elevated liver enzymes, jaundice · Opthal probs · Dermatology · seizure

Ø Clozapine (clozaril) Ø Risperidone ( risperidal) Ø Quetiapine (seroquel) Ø Olanzapine (zyprexa) Ø Ziprasidone ( geodon) DESCRIPTION Ø Block serotonin and dopamine receptors Ø Fewer side effects Ø Treating negative symptoms Ø First line treatment SIDE EFFECTS Ø Anti HAM (histaminic, adrenergic,muscarinic) Ø Agranulocytosis- clozapine Ø Lactation - risperidone Ø Seizure with clozapine Ø Olanzapine- hyperlipidemia, glucose intolerance, weight gain, liver toxicity (metabolic) Ø Quetiapine -cataracts NEUROLEPTIC MALIGNANT SYNDROME Ø Fever Ø Autonomic instability -tachy,labile HPT Ø Leukocytosis Ø Tremor Ø Elevated creatinine Phosphokinase Ø Rigidity